Cape Town is well connected. Arriving at Cape Town International Airport the airport MyCiti shuttle bus departs every 30 minutes to the city centre which is a safe and cost effective way to travel. There are also many cabs available at the airport and hotels but please use only the licensed ones.
The MyCiti bus service is quite new with dedicated bus lanes. Find their schedule and pricing here: http://www.myciti.org.za/en/home/
Trains are available but in general not advised.
Many car rental companies will come to your hotel as well as bicycle and motorcycle rental. Cape Town have a large cycling community with well maintained cycling lanes. For more info:http://www.bicyclecapetown.org
See the city on our hop-on-hop-off bus (double deck open top) with 2 routes:http://www.citysightseeing.co.za/capeTown.php